Genopathy
Gene-Disorder Association · Article
Gene
ACE
Angiotensin I Converting Enzyme
Disorder
Microvascular Complications Of Diabetes 3
First reported 1990
Supporting publications 65
Key publication · gene–disorder Management of hypertension in the diabetic patient.Clinical pharmacy · 1990
Key publication · disorder [Kimmelstiel-Wilson syndrome: diabetic nephropathy].La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris · 1950
Manually curatedApproved treatment annotated
Association Review

In brief

The association between ACE (Angiotensin I Converting Enzyme) and Microvascular Complications Of Diabetes 3 is well established and manually curated, with its 3 contributing sources — 2 of them expert-curated — recording a known molecular basis, likely-pathogenic variants, and a susceptibility locus.

Sources 3
Clinical variants 303
Symptoms 0
Compounds 9
Trials 28of 732 via ACE compounds
Publications 65
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

3 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
ACE

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Microvascular Complications Of Diabetes 3

The disorder

7 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
ClinVar and variant evidence

Genetic basis

303 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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06
Interventions

Therapeutics

9 compounds & drugs

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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07
Human studies

Clinical trials

732 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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08
Literature

Reading

65 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

15 references

Every source and publication cited across this dossier, as one numbered reference list.

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