Genopathy
Gene-Disorder Association · Article
Gene
ACKR1
Atypical Chemokine Receptor 1 (Duffy Blood Group)
Disorder
Malaria
First reported 2009
Supporting publications 4
Key publication · gene–disorder Genetic control of resistance to human malaria.Current opinion in immunology · 2009
Key publication · disorder Primaquine, SN 13272, a new curative agent in vivax malaria; a preliminary report.Journal. National Malaria Society (U.S.) · 1950
Manually curatedApproved treatment annotated
Association Review

In brief

The association between ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)) and Malaria is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording a known molecular basis and a susceptibility locus.

Sources 2
Clinical variants 0
Symptoms 22
Compounds 1
Trials 72of 151 via ACKR1 compounds
Publications 4
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
ACKR1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Malaria

The disorder

29 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

16 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Interventions

Therapeutics

1 compound or drug

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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07
Human studies

Clinical trials

151 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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08
Literature

Reading

4 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

12 references

Every source and publication cited across this dossier, as one numbered reference list.

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