Genopathy
Gene-Disorder Association · Article
Gene
ALK
ALK Receptor Tyrosine Kinase
Disorder
Neuroblastoma 3
First reported 2008
Supporting publications 10
Key publication · gene–disorder Identification of ALK as a major familial neuroblastoma predisposition gene.Nature · 2008
Key publication · disorder Combination chemotherapy with adramycin (NSC-123127) and dimethyl triazeno imidazole carboxamide (DTIC) (NSC-45388) in children with metastatic solid tumors.Medical and pediatric oncology · 1976
Manually curated
Association Review

In brief

The association between ALK (ALK Receptor Tyrosine Kinase) and Neuroblastoma 3 is well established and manually curated, with its 4 contributing sources — 3 of them expert-curated — recording a known molecular basis, pathogenic variants, causative variation, and a susceptibility locus.

Sources 4
Clinical variants 4,494
Symptoms 0
Compounds 0
Trials 0
Publications 10
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

4 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
ALK

The gene

3 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Neuroblastoma 3

The disorder

4 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
ClinVar and variant evidence

Genetic basis

4,494 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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06
Literature

Reading

10 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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07
Provenance

References & sources

15 references

Every source and publication cited across this dossier, as one numbered reference list.

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