Genopathy
Gene-Disorder Association · Article
Gene
ALOX5AP
Arachidonate 5-Lipoxygenase Activating Protein
Disorder
Stroke, Ischemic
First reported 1950
Key publication · disorder A case of cerebral infarction due to neoplastic embolism.The Journal of pathology and bacteriology · 1950
Manually curated
Association Review

In brief

The association between ALOX5AP (Arachidonate 5-Lipoxygenase Activating Protein) and Stroke, Ischemic is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording a known molecular basis and a susceptibility locus.

Sources 2
Clinical variants 0
Symptoms 16
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
ALOX5AP

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Stroke, Ischemic

The disorder

22 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
Mechanism overlap

Shared mechanisms

1 shared pathway

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
07
Provenance

References & sources

9 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access