Gene-Disorder Association · Article
Gene
APOE Apolipoprotein E
×
First reported
1994
Supporting publications
23
Manually curated Approved treatment annotated
Association Review
In brief The association between APOE (Apolipoprotein E) and Lipid Metabolism Disorder is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording likely-pathogenic variants.
Sources
2
Clinical variants
1
Symptoms
0
Compounds
2
Trials
102 of 1,023 via APOE compounds
Publications
23
Contents
01
At a glance
Association overview A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
Request access 02
Provenance
Evidence and sources 2 sources
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
Request access 1 source summary
A gene summary alongside the source descriptions it was distilled from.
Request access 04
Lipid Metabolism Disorder
The disorder 10 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
Request access 05
ClinVar and variant evidence
Genetic basis 1 clinical variant
ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.
Request access 06
Interventions
Therapeutics 2 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
Request access 07
Human studies
Clinical trials 1,023 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
Request access 23 publications
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
Request access 09
Provenance
References & sources 13 references
Every source and publication cited across this dossier, as one numbered reference list.
Request access 
