Genopathy
Gene-Disorder Association · Article
Gene
BCL10
BCL10 Immune Signaling Adaptor
Disorder
Lymphoma, Non-Hodgkin, Familial
First reported 1999
Supporting publications 6
Key publication · gene–disorder Infrequent BCL10 mutations in B-cell non-Hodgkin's lymphomas.Japanese journal of cancer research : Gann · 1999
Key publication · disorder Primary lymphosarcoma of the small intestine.Cancer · 1950
Manually curated
Association Review

In brief

The association between BCL10 (BCL10 Immune Signaling Adaptor) and Lymphoma, Non-Hodgkin, Familial is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording a known molecular basis and a susceptibility locus.

Sources 2
Clinical variants 1
Symptoms 1
Compounds 0
Trials 0
Publications 6
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
BCL10

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Lymphoma, Non-Hodgkin, Familial

The disorder

12 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
ClinVar and variant evidence

Genetic basis

1 clinical variant

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

Request access
07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
08
Literature

Reading

6 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
09
Provenance

References & sources

12 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access