Genopathy
Gene-Disorder Association · Article
Gene
BCR
BCR Activator Of RhoGEF And GTPase
Manually curatedApproved treatment annotated
Association Review

In brief

The association between BCR (BCR Activator Of RhoGEF And GTPase) and Chronic Myelogenous Leukemia, Bcr-Abl1 Positive is reported, with clinical genetic testing available.

Sources 1
Clinical variants 5
Symptoms 0
Compounds 7
Trials 372of 1,618 via BCR compounds
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
BCR

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Chronic Myelogenous Leukemia, Bcr-Abl1 Positive

The disorder

5 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
ClinVar and variant evidence

Genetic basis

5 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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06
Interventions

Therapeutics

7 compounds & drugs

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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07
Human studies

Clinical trials

1,618 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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08
Provenance

References & sources

6 references

Every source and publication cited across this dossier, as one numbered reference list.

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