Gene-Disorder Association · Article
Gene
CCL11 C-C Motif Chemokine Ligand 11
×
First reported
1997
Supporting publications
85
Manually curated Approved treatment annotated
Association Review
In brief The association between CCL11 (C-C Motif Chemokine Ligand 11) and Asthma is well established and manually curated, with its 3 contributing sources — 2 of them expert-curated — recording a known molecular basis and a susceptibility locus.
Sources
3
Clinical variants
1
Symptoms
16
Compounds
1
Trials
42 of 164 via CCL11 compounds
Publications
85
Contents
01
At a glance
Association overview A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
Request access 02
Provenance
Evidence and sources 3 sources
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
Request access 1 source summary
A gene summary alongside the source descriptions it was distilled from.
Request access 15 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
Request access 05
Phenotype
Clinical features 3 clinical features
The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.
Request access 06
ClinVar and variant evidence
Genetic basis 1 clinical variant
ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.
Request access 07
Mechanism overlap
Shared mechanisms Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.
Request access 08
Interventions
Therapeutics 1 compound or drug
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
Request access 09
Human studies
Clinical trials 164 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
Request access 85 publications
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
Request access 11
Provenance
References & sources 17 references
Every source and publication cited across this dossier, as one numbered reference list.
Request access 
