Genopathy
Gene-Disorder Association · Article
Gene
CXCR4
C-X-C Motif Chemokine Receptor 4
Disorder
Leukemia, Acute Lymphoblastic
First reported 2001
Supporting publications 3
Key publication · gene–disorder Fibronectin increases the migration induced by stromal cell-derived factor-1 alpha (SDF-1 alpha) in pre-B acute lymphoblastic leukemia cells.European cytokine network · 2001
Key publication · disorder Myelokentric acid in the treatment of acute lymphoblastic leukemia.Annals of internal medicine · 1950
Manually curated
Association Review

In brief

The association between CXCR4 (C-X-C Motif Chemokine Receptor 4) and Leukemia, Acute Lymphoblastic is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 5
Compounds 0
Trials 0
Publications 3
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
CXCR4

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Leukemia, Acute Lymphoblastic

The disorder

21 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
Literature

Reading

3 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
07
Provenance

References & sources

9 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access