Association Review
In brief The association between CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)) and Major Depressive Disorder is reported, with clinical genetic testing available.
Sources
1
Clinical variants
0
Symptoms
3
Compounds
35
Trials
483 of 3,935 via CYP2D6 compounds
Publications
0
Contents
01
At a glance
Association overview A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
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Provenance
Evidence and sources 1 source
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
Request access 1 source summary
A gene summary alongside the source descriptions it was distilled from.
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Major Depressive Disorder
The disorder 14 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
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Phenotype
Clinical features 1 clinical feature
The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.
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Population genetics
GWAS signals 1 GWAS phenotype
Gene-associated GWAS phenotypes matching the disorder, with best SNP, score, risk-allele frequency and effect size.
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Interventions
Therapeutics 35 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
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Human studies
Clinical trials 3,935 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
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Provenance
References & sources 7 references
Every source and publication cited across this dossier, as one numbered reference list.
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