Genopathy
Gene-Disorder Association · Article
Gene
CYP3A5
Cytochrome P450 Family 3 Subfamily A Member 5
Disorder
Hypertension, Essential
First reported 1950
Key publication · disorder Effects of diet in essential hypertension. II. Results with unmodified Kempner rice diet in 50 hospitalized patients.The American journal of medicine · 1950
Manually curatedApproved treatment annotated
Association Review

In brief

The association between CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) and Hypertension, Essential is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording a known molecular basis and a susceptibility locus.

Sources 2
Clinical variants 0
Symptoms 8
Compounds 18
Trials 107of 3,771 via CYP3A5 compounds
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
CYP3A5

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Hypertension, Essential

The disorder

11 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

3 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Population genetics

GWAS signals

1 GWAS phenotype

Gene-associated GWAS phenotypes matching the disorder, with best SNP, score, risk-allele frequency and effect size.

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07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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08
Interventions

Therapeutics

18 compounds & drugs

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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09
Human studies

Clinical trials

3,771 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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10
Provenance

References & sources

8 references

Every source and publication cited across this dossier, as one numbered reference list.

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