Genopathy
Gene-Disorder Association · Article
Gene
DISC1
DISC1 Scaffold Protein
Disorder
Schizophrenia
First reported 2000
Supporting publications 89
Key publication · gene–disorder Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia.Genomics · 2000
Key publication · disorder [Schizophrenia in prisoners of war; the significance of exogenous factors in schizophrenia].Medizinische Klinik · 1950
Manually curated
Association Review

In brief

The association between DISC1 (DISC1 Scaffold Protein) and Schizophrenia is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 15
Compounds 0
Trials 0
Publications 89
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
DISC1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Schizophrenia

The disorder

13 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

6 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Literature

Reading

89 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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07
Provenance

References & sources

13 references

Every source and publication cited across this dossier, as one numbered reference list.

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