Genopathy
Gene-Disorder Association · Article
Gene
ERBB2
Erb-B2 Receptor Tyrosine Kinase 2
Association Review

In brief

The association between ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2) and Lung Cancer Susceptibility 3 is supported by expert-curated evidence, drawing on a single expert-curated source, which records likely-pathogenic variants.

Sources 1
Clinical variants 6
Symptoms 0
Compounds 0
Trials 0
Publications 17
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
ERBB2

The gene

3 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Lung Cancer Susceptibility 3

The disorder

10 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
ClinVar and variant evidence

Genetic basis

6 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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06
Mechanism overlap

Shared mechanisms

1 shared pathway

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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07
Literature

Reading

17 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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08
Provenance

References & sources

16 references

Every source and publication cited across this dossier, as one numbered reference list.

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