Gene-Disorder Association · Article
Gene
ERBB4Erb-B2 Receptor Tyrosine Kinase 4
×
First reported
2001
Supporting publications
2
Manually curatedApproved treatment annotated
Association Review
In brief
The association between ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4) and Pancreatic Cancer is reported, with clinical genetic testing available.
Sources
1
Clinical variants
0
Symptoms
35
Compounds
1
Trials
31of 361 via ERBB4 compounds
Publications
2
01
At a glance
Association overview
A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
02
Provenance
Evidence and sources
1 source
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
3 source summaries
A gene summary alongside the source descriptions it was distilled from.
04
Pancreatic Cancer
The disorder
33 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
05
Phenotype
Clinical features
26 clinical features
The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.
06
Mechanism overlap
Shared mechanisms
1 shared pathway
Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.
07
Interventions
Therapeutics
1 compound or drug
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
08
Human studies
Clinical trials
361 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
2 publications
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
10
Provenance
References & sources
13 references
Every source and publication cited across this dossier, as one numbered reference list.
