Genopathy
Gene-Disorder Association · Article
Gene
FGG
Fibrinogen Gamma Chain
Disorder
Familial Dysfibrinogenemia
First reported 1974
Supporting publications 19
Key publication · gene–disorder Fibrinogen Philadelphia. A hereditary hypodysfibrinogenemia characterized by fibrinogen hypercatabolism.The Journal of clinical investigation · 1974
Key publication · disorder [FACTS IN THE POSSIBILITY OF DEMONSTRATING THE PRESENCE OF DYSFIBRINOGENEMIA].Nihon Sanka Fujinka Gakkai zasshi · 1963
Manually curated
Association Review

In brief

The association between FGG (Fibrinogen Gamma Chain) and Familial Dysfibrinogenemia is well established and manually curated, with its 3 contributing sources — 2 of them expert-curated — recording pathogenic and likely-pathogenic variants and a causative germline mutation.

Sources 3
Clinical variants 19
Symptoms 5
Compounds 0
Trials 0
Publications 19
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

3 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
FGG

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Familial Dysfibrinogenemia

The disorder

7 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

5 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
ClinVar and variant evidence

Genetic basis

19 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

Request access
07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
08
Literature

Reading

19 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
09
Provenance

References & sources

14 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access