Genopathy
Gene-Disorder Association · Article
Gene
FMO3
Flavin Containing Dimethylaniline Monoxygenase 3
Disorder
Primary Trimethylaminuria
First reported 1999
Supporting publications 35
Key publication · gene–disorder Mild trimethylaminuria caused by common variants in FMO3 gene.Lancet (London, England) · 1999
Key publication · disorder Trimethylaminuria: diet does not always control the fishy odor.The New England journal of medicine · 1976
Manually curated
Association Review

In brief

The association between FMO3 (Flavin Containing Dimethylaniline Monoxygenase 3) and Primary Trimethylaminuria is well established and manually curated, drawing on a single expert-curated source, which records pathogenic and likely-pathogenic variants.

Sources 1
Clinical variants 114
Symptoms 0
Compounds 0
Trials 0
Publications 35
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
FMO3

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Primary Trimethylaminuria

The disorder

1 database identifier

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
ClinVar and variant evidence

Genetic basis

114 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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06
Literature

Reading

35 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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07
Provenance

References & sources

10 references

Every source and publication cited across this dossier, as one numbered reference list.

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