Gene-Disorder Association · Article
Gene
GATA3 GATA Binding Protein 3
×
First reported
1999
Supporting publications
19
Manually curated Approved treatment annotated
Association Review
In brief The association between GATA3 (GATA Binding Protein 3) and Breast Cancer is reported, with clinical genetic testing available, supported by 2 contributing sources.
Sources
2
Clinical variants
0
Symptoms
4
Compounds
4
Trials
758 of 5,483 via GATA3 compounds
Publications
19
Contents
01
At a glance
Association overview A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
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Provenance
Evidence and sources 2 sources
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
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A gene summary alongside the source descriptions it was distilled from.
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Breast Cancer
The disorder 23 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
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Phenotype
Clinical features 1 clinical feature
The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.
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Genomic context
Regulatory context 4 regulatory elements
GeneHancer regulatory elements for the pair, with coordinates, score, element type and supporting literature.
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Interventions
Therapeutics 4 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
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Human studies
Clinical trials 5,483 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
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Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
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Provenance
References & sources 16 references
Every source and publication cited across this dossier, as one numbered reference list.
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