Genopathy
Gene-Disorder Association · Article
Gene
GNAI2
G Protein Subunit Alpha I2
Disorder
Ventricular Tachycardia, Familial
First reported 1974
Key publication · disorder [Familial ventricular tachycardia. Apropos of 7 cases].La Nouvelle presse medicale · 1974
Manually curated
Association Review

In brief

The association between GNAI2 (G Protein Subunit Alpha I2) and Ventricular Tachycardia, Familial is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording a known molecular basis.

Sources 2
Clinical variants 1
Symptoms 8
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
GNAI2

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Ventricular Tachycardia, Familial

The disorder

4 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

4 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
ClinVar and variant evidence

Genetic basis

1 clinical variant

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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08
Provenance

References & sources

6 references

Every source and publication cited across this dossier, as one numbered reference list.

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