Genopathy
Gene-Disorder Association · Article
Gene
GREM1
Gremlin 1, DAN Family BMP Antagonist
Disorder
Familial Adenomatous Polyposis 2
First reported 1981
Key publication · disorder Transient and steady-state kinetic studies of sodium-potassium adenosine triphosphatase using beta-(2-furyl)acryloyl phosphate as chromophoric substrate assay.Biochemistry · 1981
Manually curated
Association Review

In brief

The association between GREM1 (Gremlin 1, DAN Family BMP Antagonist) and Familial Adenomatous Polyposis 2 is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 14
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
GREM1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Familial Adenomatous Polyposis 2

The disorder

14 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

8 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
07
Provenance

References & sources

7 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access