Genopathy
Gene-Disorder Association · Article
Gene
GREM1
Gremlin 1, DAN Family BMP Antagonist
Disorder
Hereditary Mixed Polyposis Syndrome
First reported 1967
Supporting publications 1
Key publication · disorder Morphology of the male reproductive system and spermatophore of the red bollworm, Diparopsis castanea (Hmps.) and the possible effect of the chemosterilant tepa on the gross structure.The Annals of applied biology · 1967
Manually curated
Association Review

In brief

The association between GREM1 (Gremlin 1, DAN Family BMP Antagonist) and Hereditary Mixed Polyposis Syndrome is well established and manually curated, with its 2 contributing sources — 1 of them expert-curated — recording a causative germline mutation.

Sources 2
Clinical variants 4
Symptoms 19
Compounds 0
Trials 0
Publications 1
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
GREM1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Hereditary Mixed Polyposis Syndrome

The disorder

6 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

18 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
ClinVar and variant evidence

Genetic basis

4 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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08
Literature

Reading

1 publication

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

7 references

Every source and publication cited across this dossier, as one numbered reference list.

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