Genopathy
Gene-Disorder Association · Article
Gene
HCN4
Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4
Disorder
Long Qt Syndrome 11
First reported 1993
Key publication · disorder Long QT syndrome with insulin-dependent diabetes mellitus: contiguous gene syndrome on chromosome 11p.Journal of internal medicine · 1993
Manually curated
Association Review

In brief

The association between HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) and Long Qt Syndrome 11 is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 3
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
HCN4

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Long Qt Syndrome 11

The disorder

9 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

2 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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07
Provenance

References & sources

5 references

Every source and publication cited across this dossier, as one numbered reference list.

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