Genopathy
Gene-Disorder Association · Article
Gene
HLA-B
Major Histocompatibility Complex, Class I, B
Disorder
Lymphoma
First reported 1994
Supporting publications 2
Key publication · gene–disorder Binding of human beta 2-microglobulin to murine EL4 thymoma cells upregulates MHC class I heavy-chain epitopes, inhibits IL-2 secretion and induces resistance to killing by natural killer cells.Immunology letters · 1994
Key publication · disorder Use of pituitary adrenocorticotropic hormone (ACTH) and cortisone in lymphomas and leukemias.Journal of the American Medical Association · 1950
Manually curatedApproved treatment annotated
Association Review

In brief

The association between HLA-B (Major Histocompatibility Complex, Class I, B) and Lymphoma is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 0
Compounds 1
Trials 0of 500 via HLA-B compounds
Publications 2
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
HLA-B

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Lymphoma

The disorder

12 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Population genetics

GWAS signals

3 GWAS phenotypes

Gene-associated GWAS phenotypes matching the disorder, with best SNP, score, risk-allele frequency and effect size.

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06
Interventions

Therapeutics

1 compound or drug

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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07
Human studies

Clinical trials

500 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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08
Literature

Reading

2 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

6 references

Every source and publication cited across this dossier, as one numbered reference list.

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