Genopathy
Gene-Disorder Association · Article
Gene
HLA-C
Major Histocompatibility Complex, Class I, C
Disorder
Human Immunodeficiency Virus Type 1
First reported 1986
Key publication · disorder Variable and conserved neutralization antigens of human immunodeficiency virus.Nature · 1986
Manually curatedApproved treatment annotated
Association Review

In brief

The association between HLA-C (Major Histocompatibility Complex, Class I, C) and Human Immunodeficiency Virus Type 1 is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording a known molecular basis and a susceptibility locus.

Sources 2
Clinical variants 0
Symptoms 2
Compounds 1
Trials 35of 168 via HLA-C compounds
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
HLA-C

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Human Immunodeficiency Virus Type 1

The disorder

5 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Interventions

Therapeutics

1 compound or drug

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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06
Human studies

Clinical trials

168 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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07
Provenance

References & sources

6 references

Every source and publication cited across this dossier, as one numbered reference list.

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