Genopathy
Gene-Disorder Association · Article
Gene
HLA-DRB1
Major Histocompatibility Complex, Class II, DR Beta 1
Disorder
Limited Scleroderma
First reported 1962
Key publication · disorder Progressive systemic sclerosis sine scleroderma.JAMA · 1962
Manually curated
Association Review

In brief

The association between HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) and Limited Scleroderma is a manually-curated gene–disease association, drawing on a single expert-curated source, which records a susceptibility locus.

Sources 1
Clinical variants 0
Symptoms 15
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
HLA-DRB1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Limited Scleroderma

The disorder

13 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

15 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
07
Provenance

References & sources

4 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access