Gene-Disorder Association · Article
Gene
HLA-DRB1 Major Histocompatibility Complex, Class II, DR Beta 1
×
First reported
1950
Supporting publications
1
Manually curated Approved treatment annotated
Association Review
In brief The association between HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) and Systemic-Onset Juvenile Idiopathic Arthritis is a manually-curated gene–disease association, drawing on a single expert-curated source, which records a susceptibility locus.
Sources
1
Clinical variants
0
Symptoms
22
Compounds
3
Trials
4 of 704 via HLA-DRB1 compounds
Publications
1
Contents
01
At a glance
Association overview A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
Request access 02
Provenance
Evidence and sources 1 source
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
Request access 1 source summary
A gene summary alongside the source descriptions it was distilled from.
Request access 04
Systemic-Onset Juvenile Idiopathic Arthritis
The disorder 5 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
Request access 05
Phenotype
Clinical features 22 clinical features
The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.
Request access 06
Mechanism overlap
Shared mechanisms Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.
Request access 07
Interventions
Therapeutics 3 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
Request access 08
Human studies
Clinical trials 704 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
Request access 1 publication
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
Request access 10
Provenance
References & sources 6 references
Every source and publication cited across this dossier, as one numbered reference list.
Request access 
