Gene-Disorder Association · Article
Gene
HTRA1 HtrA Serine Peptidase 1
×
First reported
1985
Supporting publications
5
Approved treatment annotated
Association Review
In brief The association between HTRA1 (HtrA Serine Peptidase 1) and Kuhnt-Junius Degeneration is supported by expert-curated evidence, supported by a single expert-curated source.
Sources
1
Clinical variants
1
Symptoms
0
Compounds
2
Trials
79 of 3,018 via HTRA1 compounds
Publications
5
Contents
01
At a glance
Association overview A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
Request access 02
Provenance
Evidence and sources 1 source
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
Request access 1 source summary
A gene summary alongside the source descriptions it was distilled from.
Request access 04
Kuhnt-Junius Degeneration
The disorder 5 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
Request access 05
ClinVar and variant evidence
Genetic basis 1 clinical variant
ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.
Request access 06
Interventions
Therapeutics 2 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
Request access 07
Human studies
Clinical trials 3,018 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
Request access 5 publications
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
Request access 09
Provenance
References & sources 9 references
Every source and publication cited across this dossier, as one numbered reference list.
Request access 
