Genopathy
Gene-Disorder Association · Article
Gene
IDH2
Isocitrate Dehydrogenase (NADP(+)) 2
Disorder
Leukemia, Acute Myeloid
First reported 1950
Supporting publications 1
Key publication · disorder [Septic pharyngeal diphtheria followed by acute myeloid leukemia].Osterreichische Zeitschrift fur Kinderheilkunde und Kinderfursorge · 1950
Manually curatedApproved treatment annotated
Association Review

In brief

The association between IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) and Leukemia, Acute Myeloid is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording causative variation.

Sources 2
Clinical variants 0
Symptoms 5
Compounds 10
Trials 1,047of 2,450 via IDH2 compounds
Publications 1
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
IDH2

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Leukemia, Acute Myeloid

The disorder

27 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Interventions

Therapeutics

10 compounds & drugs

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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07
Human studies

Clinical trials

2,450 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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08
Literature

Reading

1 publication

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

10 references

Every source and publication cited across this dossier, as one numbered reference list.

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