Genopathy
Gene-Disorder Association · Article
Gene
IFNGR1
Interferon Gamma Receptor 1
Disorder
Helicobacter Pylori Infection
First reported 2003
Supporting publications 3
Key publication · gene–disorder Genomewide linkage analysis identifies polymorphism in the human interferon-gamma receptor affecting Helicobacter pylori infection.American journal of human genetics · 2003
Key publication · disorder Unidentified curved bacilli on gastric epithelium in active chronic gastritis.Lancet (London, England) · 1983
Manually curated
Association Review

In brief

The association between IFNGR1 (Interferon Gamma Receptor 1) and Helicobacter Pylori Infection is well established and manually curated, with its 3 contributing sources — 2 of them expert-curated — recording a known molecular basis, pathogenic variants, and a susceptibility locus.

Sources 3
Clinical variants 8
Symptoms 12
Compounds 0
Trials 0
Publications 3
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

3 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
IFNGR1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Helicobacter Pylori Infection

The disorder

4 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
ClinVar and variant evidence

Genetic basis

8 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

Request access
07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
08
Literature

Reading

3 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
09
Provenance

References & sources

9 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access