Gene-Disorder Association · Article
Gene
IGHImmunoglobulin Heavy Locus
×
First reported
1996
Supporting publications
2
Manually curatedApproved treatment annotated
Association Review
In brief
The association between IGH (Immunoglobulin Heavy Locus) and Lymphoma, Non-Hodgkin, Familial is reported, with clinical genetic testing available.
Sources
1
Clinical variants
0
Symptoms
1
Compounds
1
Trials
13of 64 via IGH compounds
Publications
2
01
At a glance
Association overview
A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
02
Provenance
Evidence and sources
1 source
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
1 source summary
A gene summary alongside the source descriptions it was distilled from.
04
Lymphoma, Non-Hodgkin, Familial
The disorder
12 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
05
Phenotype
Clinical features
1 clinical feature
The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.
06
Mechanism overlap
Shared mechanisms
Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.
07
Interventions
Therapeutics
1 compound or drug
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
08
Human studies
Clinical trials
64 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
2 publications
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
10
Provenance
References & sources
7 references
Every source and publication cited across this dossier, as one numbered reference list.
