Genopathy
Gene-Disorder Association · Article
Gene
IL10
Interleukin 10
Disorder
Human Immunodeficiency Virus Type 1
First reported 2000
Supporting publications 3
Key publication · gene–disorder Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.Proceedings of the National Academy of Sciences of the United States of America · 2000
Key publication · disorder Variable and conserved neutralization antigens of human immunodeficiency virus.Nature · 1986
Manually curatedApproved treatment annotated
Association Review

In brief

The association between IL10 (Interleukin 10) and Human Immunodeficiency Virus Type 1 is well established and manually curated, with its 3 contributing sources — 2 of them expert-curated — recording a known molecular basis and a susceptibility locus.

Sources 3
Clinical variants 2
Symptoms 2
Compounds 1
Trials 70of 313 via IL10 compounds
Publications 3
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

3 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
IL10

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Human Immunodeficiency Virus Type 1

The disorder

5 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
ClinVar and variant evidence

Genetic basis

2 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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06
Interventions

Therapeutics

1 compound or drug

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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07
Human studies

Clinical trials

313 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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08
Literature

Reading

3 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

10 references

Every source and publication cited across this dossier, as one numbered reference list.

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