Genopathy
Gene-Disorder Association · Article
Gene
IL10
Interleukin 10
Disorder
Systemic Lupus Erythematosus
First reported 1993
Supporting publications 38
Key publication · gene–disorder Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus.European cytokine network · 1993
Key publication · disorder Blood factor in acute disseminated lupus erythematosus; determination of gamma globulin as specific plasma fraction.The American journal of the medical sciences · 1950
Manually curated
Association Review

In brief

The association between IL10 (Interleukin 10) and Systemic Lupus Erythematosus is a manually-curated gene–disease association, drawing on a single expert-curated source, which records a susceptibility locus.

Sources 1
Clinical variants 0
Symptoms 64
Compounds 0
Trials 0
Publications 38
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
IL10

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Systemic Lupus Erythematosus

The disorder

23 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

52 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
Population genetics

GWAS signals

1 GWAS phenotype

Gene-associated GWAS phenotypes matching the disorder, with best SNP, score, risk-allele frequency and effect size.

Request access
07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
08
Literature

Reading

38 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
09
Provenance

References & sources

15 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access