Genopathy
Gene-Disorder Association · Article
Gene
ING1
Inhibitor Of Growth Family Member 1
Disorder
Squamous Cell Carcinoma, Head And Neck
First reported 2000
Supporting publications 1
Key publication · gene–disorder Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.Cancer research · 2000
Key publication · disorder Carcinoma of the head and neck.The Journal of the Florida Medical Association. Florida Medical Association · 1950
Manually curated
Association Review

In brief

The association between ING1 (Inhibitor Of Growth Family Member 1) and Squamous Cell Carcinoma, Head And Neck is well established and manually curated, with its 5 contributing sources — 4 of them expert-curated — recording a known molecular basis, pathogenic variants, and causative variation.

Sources 5
Clinical variants 3
Symptoms 9
Compounds 0
Trials 0
Publications 1
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

5 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
ING1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Squamous Cell Carcinoma, Head And Neck

The disorder

32 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
ClinVar and variant evidence

Genetic basis

3 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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08
Literature

Reading

1 publication

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

10 references

Every source and publication cited across this dossier, as one numbered reference list.

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