Genopathy
Gene-Disorder Association · Article
Gene
JAK2
Janus Kinase 2
Disorder
Hypereosinophilic Syndrome
First reported 1950
Key publication · disorder Facial granulomas with eosinophilia; their relation to other eosinophilic granulomas of the skin and to reticulogranuloma.Archives of dermatology and syphilology · 1950
Approved treatment annotated
Association Review

In brief

The association between JAK2 (Janus Kinase 2) and Hypereosinophilic Syndrome is supported by expert-curated evidence, drawing on a single expert-curated source, which records likely-pathogenic variants.

Sources 1
Clinical variants 0
Symptoms 15
Compounds 2
Trials 9of 709 via JAK2 compounds
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
JAK2

The gene

3 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Hypereosinophilic Syndrome

The disorder

12 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Interventions

Therapeutics

2 compounds & drugs

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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06
Human studies

Clinical trials

709 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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07
Provenance

References & sources

7 references

Every source and publication cited across this dossier, as one numbered reference list.

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