Gene-Disorder Association · Article
Gene
MAPTMicrotubule Associated Protein Tau
×
First reported
1993
Supporting publications
42
Manually curatedApproved treatment annotated
Association Review
In brief
The association between MAPT (Microtubule Associated Protein Tau) and Parkinson'S Disease is reported, with clinical genetic testing available.
Sources
1
Clinical variants
12
Symptoms
13
Compounds
3
Trials
66of 107 via MAPT compounds
Publications
42
01
At a glance
Association overview
A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
02
Provenance
Evidence and sources
1 source
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
1 source summary
A gene summary alongside the source descriptions it was distilled from.
04
Parkinson'S Disease
The disorder
7 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
05
ClinVar and variant evidence
Genetic basis
12 clinical variants
ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.
06
Mechanism overlap
Shared mechanisms
2 shared pathways
Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.
07
Interventions
Therapeutics
3 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
08
Human studies
Clinical trials
107 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
42 publications
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
10
Provenance
References & sources
18 references
Every source and publication cited across this dossier, as one numbered reference list.
