Genopathy
Gene-Disorder Association · Article
Gene
MRAS
Muscle RAS Oncogene Homolog
Disorder
Rasopathy
First reported 2020
Supporting publications 4
Key publication · gene–disorder Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.Human molecular genetics · 2020
Key publication · disorder Electron microscope studies on Ophiostoma multiannulatum.Hereditas · 1967
Manually curated
Association Review

In brief

The association between MRAS (Muscle RAS Oncogene Homolog) and Rasopathy is well established and manually curated, with its 2 contributing sources — 1 of them expert-curated — recording likely-pathogenic variants.

Sources 2
Clinical variants 7
Symptoms 0
Compounds 0
Trials 0
Publications 4
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
MRAS

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Rasopathy

The disorder

4 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
ClinVar and variant evidence

Genetic basis

7 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

Request access
06
Literature

Reading

4 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
07
Provenance

References & sources

7 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access