Gene-Disorder Association · Article
Gene
MYH7 Myosin Heavy Chain 7
×
First reported
1990
Supporting publications
549
Manually curated Approved treatment annotated
Association Review
In brief The association between MYH7 (Myosin Heavy Chain 7) and Hypertrophic Cardiomyopathy is well established and manually curated, with its 2 contributing sources — 1 of them expert-curated — recording pathogenic and likely-pathogenic variants.
Sources
2
Clinical variants
3,741
Symptoms
0
Compounds
2
Trials
33 of 36 via MYH7 compounds
Publications
549
Contents
01
At a glance
Association overview A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
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Provenance
Evidence and sources 2 sources
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
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A gene summary alongside the source descriptions it was distilled from.
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Hypertrophic Cardiomyopathy
The disorder 8 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
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ClinVar and variant evidence
Genetic basis 3,741 clinical variants
ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.
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Interventions
Therapeutics 2 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
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Human studies
Clinical trials 36 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
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Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
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Provenance
References & sources 14 references
Every source and publication cited across this dossier, as one numbered reference list.
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