Genopathy
Gene-Disorder Association · Article
Gene
PLAT
Plasminogen Activator, Tissue Type
Disorder
Thrombophilia Due To Thrombin Defect
First reported 1990
Supporting publications 12
Key publication · gene–disorder Randomized controlled trial of tissue plasminogen activator in proximal deep venous thrombosis.The American journal of medicine · 1990
Key publication · disorder Post-operative venous thrombosis and pulmonary embolism with particular reference to current methods of treatment.Annals of the Royal College of Surgeons of England · 1950
Manually curated
Association Review

In brief

The association between PLAT (Plasminogen Activator, Tissue Type) and Thrombophilia Due To Thrombin Defect is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 8
Compounds 0
Trials 0
Publications 12
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
PLAT

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Thrombophilia Due To Thrombin Defect

The disorder

13 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

5 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Literature

Reading

12 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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07
Provenance

References & sources

12 references

Every source and publication cited across this dossier, as one numbered reference list.

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