Genopathy
Gene-Disorder Association · Article
Gene
PTEN
Phosphatase And Tensin Homolog
Disorder
Glioma
First reported 1997
Supporting publications 79
Key publication · gene–disorder Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.Proceedings of the National Academy of Sciences of the United States of America · 1997
Key publication · disorder [Contribution to the cytokaryologic study of glioma. Note II. Karyology of some tumoral cytotypes of glioma and of the hyperplastic astrocytary glia].Rivista di anatomia patologica e di oncologia · 1950
Manually curatedApproved treatment annotated
Association Review

In brief

The association between PTEN (Phosphatase And Tensin Homolog) and Glioma is well established and manually curated, with its 2 contributing sources — 1 of them expert-curated — recording pathogenic variants.

Sources 2
Clinical variants 3
Symptoms 0
Compounds 2
Trials 12of 295 via PTEN compounds
Publications 79
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
PTEN

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Glioma

The disorder

1 database identifier

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
ClinVar and variant evidence

Genetic basis

3 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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06
Interventions

Therapeutics

2 compounds & drugs

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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07
Human studies

Clinical trials

295 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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08
Literature

Reading

79 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

14 references

Every source and publication cited across this dossier, as one numbered reference list.

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