Genopathy
Gene-Disorder Association · Article
Gene
PTPN11
Protein Tyrosine Phosphatase Non-Receptor Type 11
Disorder
Leukemia
First reported 2003
Supporting publications 28
Key publication · gene–disorder The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.Trends in biochemical sciences · 2003
Key publication · disorder Use of pituitary adrenocorticotropic hormone (ACTH) and cortisone in lymphomas and leukemias.Journal of the American Medical Association · 1950
Manually curated
Association Review

In brief

The association between PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) and Leukemia is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 3
Compounds 0
Trials 0
Publications 28
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
PTPN11

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Leukemia

The disorder

8 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Literature

Reading

28 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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06
Provenance

References & sources

12 references

Every source and publication cited across this dossier, as one numbered reference list.

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