Genopathy
Gene-Disorder Association · Article
Gene
RAD51L3-RFFL
RAD51L3-RFFL Readthrough
Disorder
Breast-Ovarian Cancer, Familial 4
First reported 1998
Supporting publications 66
Key publication · disorder [Sequence analysis of BRCA1 gene in young breast cancer patients and/or positive family history].Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress · 1998
Manually curated
Association Review

In brief

The association between RAD51L3-RFFL (RAD51L3-RFFL Readthrough) and Breast-Ovarian Cancer, Familial 4 is well established and manually curated, drawing on a single expert-curated source, which records pathogenic variants.

Sources 1
Clinical variants 1,563
Symptoms 0
Compounds 0
Trials 0
Publications 66
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
RAD51L3-RFFL

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Breast-Ovarian Cancer, Familial 4

The disorder

7 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
ClinVar and variant evidence

Genetic basis

1,563 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

Request access
06
Literature

Reading

66 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
07
Provenance

References & sources

10 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access