Genopathy
Gene-Disorder Association · Article
Gene
SDHA
Succinate Dehydrogenase Complex Flavoprotein Subunit A
Disorder
Leber Hereditary Optic Neuropathy, Modifier Of
First reported 1950
Key publication · disorder Molybdenum deficiency in Dunkirk silty clay loam.Science (New York, N.Y.) · 1950
Manually curated
Association Review

In brief

The association between SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A) and Leber Hereditary Optic Neuropathy, Modifier Of is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 28
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
SDHA

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Leber Hereditary Optic Neuropathy, Modifier Of

The disorder

14 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

26 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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07
Provenance

References & sources

7 references

Every source and publication cited across this dossier, as one numbered reference list.

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