Genopathy
Gene-Disorder Association · Article
Gene
SRD5A2
Steroid 5 Alpha-Reductase 2
Disorder
Prostate Cancer
First reported 1999
Supporting publications 40
Key publication · gene–disorder Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA.Lancet (London, England) · 1999
Key publication · disorder Endocrine control of prostatic carcinoma; clinical and statistical survey of 1,818 cases.Journal of the American Medical Association · 1950
Manually curatedApproved treatment annotated
Association Review

In brief

The association between SRD5A2 (Steroid 5 Alpha-Reductase 2) and Prostate Cancer is a manually-curated gene–disease association, supported by a single expert-curated source.

Sources 1
Clinical variants 0
Symptoms 5
Compounds 2
Trials 285of 323 via SRD5A2 compounds
Publications 40
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
SRD5A2

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Prostate Cancer

The disorder

20 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
Interventions

Therapeutics

2 compounds & drugs

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

Request access
07
Human studies

Clinical trials

323 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

Request access
08
Literature

Reading

40 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

Request access
09
Provenance

References & sources

16 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access