Genopathy
Gene-Disorder Association · Article
Gene
STAT4
Signal Transducer And Activator Of Transcription 4
Disorder
Systemic Lupus Erythematosus 11
First reported 1988
Supporting publications 4
Key publication · disorder Correlation of the activation of the fourth component of complement (C4) with disease activity in systemic lupus erythematosus.Annals of the rheumatic diseases · 1988
Manually curated
Association Review

In brief

The association between STAT4 (Signal Transducer And Activator Of Transcription 4) and Systemic Lupus Erythematosus 11 is well established and manually curated, with its 3 contributing sources — 2 of them expert-curated — recording a known molecular basis and a susceptibility locus.

Sources 3
Clinical variants 2
Symptoms 1
Compounds 0
Trials 0
Publications 4
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

3 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
STAT4

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Systemic Lupus Erythematosus 11

The disorder

5 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
ClinVar and variant evidence

Genetic basis

2 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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07
Population genetics

GWAS signals

1 GWAS phenotype

Gene-associated GWAS phenotypes matching the disorder, with best SNP, score, risk-allele frequency and effect size.

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08
Literature

Reading

4 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

9 references

Every source and publication cited across this dossier, as one numbered reference list.

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