Gene-Disorder Association · Article
Gene
TET2 Tet Methylcytosine Dioxygenase 2
×
First reported
1950
Supporting publications
1
Manually curated Approved treatment annotated
Association Review
In brief The association between TET2 (Tet Methylcytosine Dioxygenase 2) and Leukemia, Acute Myeloid is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording causative variation.
Sources
2
Clinical variants
0
Symptoms
5
Compounds
3
Trials
406 of 2,583 via TET2 compounds
Publications
1
Contents
01
At a glance
Association overview A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
Request access 02
Provenance
Evidence and sources 2 sources
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
Request access 1 source summary
A gene summary alongside the source descriptions it was distilled from.
Request access 04
Leukemia, Acute Myeloid
The disorder 27 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
Request access 05
Phenotype
Clinical features 1 clinical feature
The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.
Request access 06
Mechanism overlap
Shared mechanisms Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.
Request access 07
Interventions
Therapeutics 3 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
Request access 08
Human studies
Clinical trials 2,583 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
Request access 1 publication
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
Request access 10
Provenance
References & sources 9 references
Every source and publication cited across this dossier, as one numbered reference list.
Request access 
