Genopathy
Gene-Disorder Association · Article
Gene
TNF
Tumor Necrosis Factor
Disorder
Malaria
Manually curatedApproved treatment annotated
Association Review

In brief

The association between TNF (Tumor Necrosis Factor) and Malaria is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording a known molecular basis and a susceptibility locus.

Sources 2
Clinical variants 0
Symptoms 22
Compounds 2
Trials 72of 581 via TNF compounds
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
TNF

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Malaria

The disorder

29 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

16 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Interventions

Therapeutics

2 compounds & drugs

Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.

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07
Human studies

Clinical trials

581 clinical trials

Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.

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08
Provenance

References & sources

9 references

Every source and publication cited across this dossier, as one numbered reference list.

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