Gene-Disorder Association · Article
Gene
TP53Tumor Protein P53
×
First reported
1992
Supporting publications
70
Manually curatedApproved treatment annotated
Association Review
In brief
The association between TP53 (Tumor Protein P53) and Lung Non-Small Cell Carcinoma is reported, with clinical genetic testing available.
Sources
1
Clinical variants
0
Symptoms
0
Compounds
21
Trials
2,612of 15,420 via TP53 compounds
Publications
70
01
At a glance
Association overview
A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.
02
Provenance
Evidence and sources
1 source
Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.
3 source summaries
A gene summary alongside the source descriptions it was distilled from.
04
Lung Non-Small Cell Carcinoma
The disorder
6 database identifiers
The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).
05
Mechanism overlap
Shared mechanisms
1 shared pathway
Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.
06
Interventions
Therapeutics
21 compounds & drugs
Gene-targeting drugs and associated compounds, with class, approval status, mechanism, indications and trials.
07
Human studies
Clinical trials
15,420 clinical trials
Clinical trials reached through the pair’s compounds, keeping disorder-targeting trials separate from other indications.
70 publications
Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.
09
Provenance
References & sources
18 references
Every source and publication cited across this dossier, as one numbered reference list.
