Genopathy
Gene-Disorder Association · Article
Gene
TRAF3IP2
TRAF3 Interacting Protein 2
Disorder
Psoriasis 13
First reported 2010
Supporting publications 4
Key publication · gene–disorder Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.Nature genetics · 2010
Key publication · disorder [Psoriasis vulgaris].Priroda, clovek in zdravje · 1950
Manually curated
Association Review

In brief

The association between TRAF3IP2 (TRAF3 Interacting Protein 2) and Psoriasis 13 is well established and manually curated, with its 3 contributing sources — 2 of them expert-curated — recording a known molecular basis, likely-pathogenic variants, and a susceptibility locus.

Sources 3
Clinical variants 7
Symptoms 4
Compounds 0
Trials 0
Publications 4
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

3 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
TRAF3IP2

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Psoriasis 13

The disorder

8 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
ClinVar and variant evidence

Genetic basis

7 clinical variants

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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07
Population genetics

GWAS signals

1 GWAS phenotype

Gene-associated GWAS phenotypes matching the disorder, with best SNP, score, risk-allele frequency and effect size.

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08
Literature

Reading

4 publications

Publications linking the gene and the disorder, with title, authors, journal, year and citation metrics.

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09
Provenance

References & sources

10 references

Every source and publication cited across this dossier, as one numbered reference list.

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