Genopathy
Gene-Disorder Association · Article
Gene
WNK1
WNK Lysine Deficient Protein Kinase 1
Disorder
Pseudohypoaldosteronism, Type Iie
First reported 1978
Key publication · disorder Familial hyperpotassemia and hypertension accompanied by normal plasma aldosterone levels: possible hereditary cell membrane defect.Archives of internal medicine · 1978
Manually curated
Association Review

In brief

The association between WNK1 (WNK Lysine Deficient Protein Kinase 1) and Pseudohypoaldosteronism, Type Iie is reported, with clinical genetic testing available.

Sources 1
Clinical variants 0
Symptoms 17
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

Request access
02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

Request access
03
WNK1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

Request access
04
Pseudohypoaldosteronism, Type Iie

The disorder

13 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

Request access
05
Phenotype

Clinical features

13 clinical features

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

Request access
06
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

Request access
07
Provenance

References & sources

6 references

Every source and publication cited across this dossier, as one numbered reference list.

Request access