Genopathy
Gene-Disorder Association · Article
Gene
WNT1
Wnt Family Member 1
Disorder
Osteoporosis
First reported 1950
Key publication · disorder [The prefractural femoral neck in simple, senile osteoporosis].Schweizerische Zeitschrift fur Pathologie und Bakteriologie. Revue suisse de pathologie et de bacteriologie · 1950
Manually curated
Association Review

In brief

The association between WNT1 (Wnt Family Member 1) and Osteoporosis is a manually-curated gene–disease association, drawing on a single expert-curated source, which records causative variation.

Sources 1
Clinical variants 0
Symptoms 9
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

1 source

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
WNT1

The gene

1 source summary

A gene summary alongside the source descriptions it was distilled from.

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04
Osteoporosis

The disorder

21 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
Phenotype

Clinical features

1 clinical feature

The disorder’s clinical features (HPO) grouped by body system, each with observed frequency and penetrance.

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06
Population genetics

GWAS signals

1 GWAS phenotype

Gene-associated GWAS phenotypes matching the disorder, with best SNP, score, risk-allele frequency and effect size.

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07
Mechanism overlap

Shared mechanisms

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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08
Provenance

References & sources

6 references

Every source and publication cited across this dossier, as one numbered reference list.

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