Genopathy
Gene-Disorder Association · Article
Gene
WT1
WT1 Transcription Factor
Disorder
Primary Ovarian Insufficiency
First reported 2006
Key publication · gene–disorder Hypergonadotropic hypogonadism and renal failure due to WT1 mutation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2006
Key publication · disorder Primary ovarian failure.The Journal of clinical endocrinology and metabolism · 1953
Manually curated
Association Review

In brief

The association between WT1 (WT1 Transcription Factor) and Primary Ovarian Insufficiency is a manually-curated gene–disease association, with its 2 contributing sources — 1 of them expert-curated — recording likely-pathogenic variants.

Sources 2
Clinical variants 1
Symptoms 1
Compounds 0
Trials 0
Publications 0
01
At a glance

Association overview

A cited synthesis of the gene–disorder association, with a clinical-actionability summary where the evidence supports one.

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02
Provenance

Evidence and sources

2 sources

Every contributing database and publication behind this association, with evidence type, strength, accessions and deep links.

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03
WT1

The gene

2 source summaries

A gene summary alongside the source descriptions it was distilled from.

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04
Primary Ovarian Insufficiency

The disorder

7 database identifiers

The disorder’s summary, prevalence, aliases and cross-reference identifiers (OMIM, Orphanet, MONDO, ICD-10, MedGen).

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05
ClinVar and variant evidence

Genetic basis

1 clinical variant

ClinVar variants reported for this pair, with disorder-specific significance, review status, molecular consequence and origin.

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06
Mechanism overlap

Shared mechanisms

1 shared pathway

Biological pathways and phenotype concepts shared by the gene and the disorder, with supporting publications.

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07
Provenance

References & sources

6 references

Every source and publication cited across this dossier, as one numbered reference list.

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